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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
UNUSUAL RESPONSE TO ELTROMBOPAG AND DOSE ADJUSTMENT IN PATIENT WITH A DIAGNOSIS OF REFRACTORY IMMUNE THROMBOCYTOPENIA
Author
Mehmet Hilmi Dogu*, Ismail Sari, Sibel Hacioglu, Ali Keskin
Email
mhdogu@yahoo.com
keyword
Thrombocytopenia, Thrombopoietin receptor, Eltrombopag.
Abstract
Immune thrombocytopenia (ITP) is an acquired autoimmune disease with isolated thrombocytopenia in which myeloid and erythroid series not affected. Refractory ITP is a term used in ITP patients with thrombocytopenia despite corticosteroid therapy and splenectomy. Treatment in refractory ITP is initiated depending on the grade of thrombocytopenia and in presence of bleeding and clinical conditions requiring therapy. Most commonly used agent in this patient group is eltrombopag which is a thrombopoietin (TPO) mimetic. Based on these information, we report a case from our clinic with unusual response to eltrombopag and subsequent dose adjustment for this response; since there no drug use matching this dose adjustment in the literature.
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