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American Journal of Advances in Nursing Research

Volume 11, Issue 2, 2024
Mcmed International
American Journal of Advances in Nursing Research
Issn
XXX-XXXX (Print), 2349 – 0691 (Online)
Frequency
bi-annual
Email
editorajanr@mcmed.us
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Abstract
Title
EFFICACY OF TESTOSTERONE SUPPLEMENATION ON COGNITIVE FUNCTION: A META-ANALYSIS
Author
Mee-Young Im and Seung-Kwon Myung
Email
msk@ncc.re.kr
keyword
Testosterone; Cognition; Randomized Controlled Trials; Meta-analysis.
Abstract
Previous randomized controlled trials (RCTs) have reported inconsistent findings regarding the efficacy of testosterone supplementation on cognitive function. We performed a meta-analysis of RCTs to investigate the efficacy of testosterone supplementation on cognitive function. We searched PubMed, EMBASE, Cochrane Library, and relevant bibliographies in August 2015, using common keywords related to testosterone supplementation and cognition. Out of 245 articles retrieved from databases, a total of 10 RCTs, which involved 554 participants (277 intervention and 277 placebo groups), were included in the final analysis. A fixed-effect meta-analysis of all 10 RCTs revealed that testosterone supplementation had no efficacy on cognitive functions such as spatial memory (standardized mean difference [SMD], -0.06, 95% confidence interval [CI], -0.24, 0.12), verbal memory (SMD, -0.07; 95% CI, -0.25, 0.11), visual memory (SMD, -0.08; 95% CI, -0.27, 0.12), working memory (SMD, -0.18; 95% CI, -0.44, 0.07), verbal ability (SMD, -0.16; 95% CI, -0.59, 0.27), cognitive processing speed (SMD, -0.06; 95% CI, -0.26, 0.14), and executive functioning (SMD, -0.04; 95% CI, -0.22, 0.15). Similarly, subgroup meta-analyses by testosterone levels of study participants showed that there was no significant difference in cognitive function between the two groups. The current meta-analysis of RCTs found that there is no sufficient clinical evidence to support the use of testosterone supplementation for the improvement on cognitive function.
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