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American Journal of Oral Medicine and Radiology

Volume 5, Issue 2, 2018
Mcmed International
American Journal of Oral Medicine and Radiology
Issn
XXX-XXXX (Print), 2394 - 7721 (Online)
Frequency
bi-annual
Email
editorajomr@mcmed.us
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Abstract
Title
SNAIL EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA
Author
Sahana NS *, Asha R Iyengar, Vijaya Mysorekar, Pavana Gopinath
Email
drsahanans@gmail.com
keyword
Epithelial- Mesenchymal Transition, SNAIL, E- Cadherin.
Abstract
Epithelial-Mesenchymal Transition [EMT] describes a process in which epithelial cells undergo alterations in cellular architecture, adhesion, migratory and invasive capabilities. Among the mechanisms largely associated with the metastatic conversation of epithelial cells and the EMT, the loss of E-Cadherin-mediated cell adhesion is prominent and is considered to be a fundamental event. SNAIL (SNAI1), the first EMT inducer originally implicated with tumor progression belongs to a family of zinc-finger transcription factors. Binding of SNAI1 to E-box elements in the E-Cadherin promoter region leads to transcriptional repression of the CDH1 gene and resulting in loss of E-cadherin expression, which is considered a “hallmark” of EMT. This study is designed to evaluate and compare SNAIL1 expression in Oral Squamous Cell Carcinoma [OSCC] to normal oral mucosa [NOM]. Formalin fixed paraffin embedded tissues of diagnosed cases of Oral SCC (n=30) and oral mucosa (n=30), were examined for the expression of SNAIL by standard immunohistochemistry protocol using snail1 antibody. All data were tabulated and statistically analyzed. Snail1 expression was observed in the epithelium and in the stromal elements of the sections, and the expression was significantly associated with the lesion’s extension. Highly significant difference was reported among the two groups. (P <0.001). Expression of Snail1 at the invasive front in oral squamous cell carcinomas suggests a key role of EMT in the tumorogenesis of this cancer.
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