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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
CLINICAL PROFILE OF PLASMA CELL LEUKEMIA AT TERTIARY CARE HOSPITAL IN KASHMIR, INDIA
Author
Javvid Muzamil*, Shiekh Aejaz Aziz, Gull Mohammad Bhat, Abdul Rashid Lone, Shuaeb Bhat, Firdousa Nabi
Email
Javvidmd@gmail.com
keyword
pPCL- Primary plasma cell leukemia, sPCL- Secondary plasma cell leukemia, MM- Multiple myeloma, LDH- Lactate dehydrogenase, PBF- Peripheral blood film, P.A.S- Per iodic acid Schiff, S.B- Sudan black stain.
Abstract
Plasma cell dyscrasias represent 1.4-2 % of all malignancies and among hematologic malignancies; it constitutes 10 % of the tumors. Plasma cell dyscrasias are composed of multiple myeloma, primary and secondary plasma cell leukemia. Primary plasma cell leukemia (pPCL) is a rare and aggressive disease, represents 1-4 % of plasma cell dyscrasias. The prognosis of this is very poor with median survival of 8- 11 months in different reported series. We are reporting a study from our hospital over a period of ten years, in which pPCL was found in 1.8% of multiple myeloma patients, with slight male predominance and earlier age than multiple myeloma, and all had high disease burden with high LDH, β2 microglobulin, and plasmacytosis. This disease had very aggressive behavior especially with light chain lambda disease and all patients succumbed within 8 months of treatment.
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