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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
PURIFICATION AND CHARACTERIZATION OF GLYCOLIPID BIOSURFACTANT FROM AN ESTUARINE YEAST Candida tropicalis
Author
Thenmozhi M and Boominathan M*
Email
master.maniji@gmail.com
keyword
Candida tropicalis; glycolipid biosurfactant; critical micelle concentration; board stability; antimicrobial activity.
Abstract
A potential biosurfactant producing estuarine yeast Candida tropicalis was isolated from the mangrove sediment of Vellar estuary, Porto Novo, Tamilnadu, India. The biosurfactant was produced using yeast malt broth and purified using acid precipitation followed by silica gel column chromatography. The purified biosurfactant was found to be a glycolipid surfactant characterized using TLC, FT-IR and NMR. Stability testing of biosurfactant revealed that it had broader range of stability to over pH 4-9, temperature up to 80ºC and salinity from 0 ppt to 50 ppt. The glycolipid biosurfactant showed excellent antimicrobial activity against many human bacterial and fungal pathogens viz., bacterial strains of Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Vibrio cholerae, Bacillus subtilis, Salmonella paratyphi and Staphylococcus aureus and fungal strains of Cryptococcus neoformans, Candida albicans and Aspergillus niger. Thus in the present study, the glycolipid biosurfactant produced by Candida tropicalis, an estuarine yeast was found to be an ideal product for the possible development of antimicrobial therapeutic drugs.
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