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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
EVALUATION OF ANALGESIC ACTIVITY OF METHANOL AND CHLOROFORM EXTRACTS OF ANTIGONON LEPTOPUS
Author
Poonam Ranjan, Sushil Pratap, Dilip Kumar Tiwari, Kishu Tripathi*
Email
kishutripathi@rediffmail.com
keyword
Antigonon leptopus, Analgesic activity, Methanol extract, Chloroform extract, tail immersion model.
Abstract
To investigate the analgesic activities of methanol and chloroform extracts of Antigonon leptopus (MEAL and CEAL respectively) leaves in albino rats. Analgesic activity was evaluated using tail immersion techniques, by measuring the reaction time of the animals treated with either standard or extract at dose levels of 50, 100, 150, 200 and 250 mg/kg p.o. Tramadol HCl (10 mg/kg) was used as reference standard. In the experimental study, the extracts showed reaction times of 6.15(p < 0.05) and 7.00 (p < 0.05) sec at the doses of 100 and 150 mg/kg of MEAL after 30 min and 5.00(p < 0.05) and 5.50 (p < 0.05) sec at the doses of 150 and 100 mg/kg of CEAL after 60 min, respectively in the tail immersion model. All results occur in dose dependent manner. Based on the findings, it can be concluded that Antigonon leptopus possesses analgesic property and this lends some support for its use in traditional medical practice.
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