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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
ANTHELMINTIC ACTIVITY OF 3-ARYLIDENE-5-(BIPHENYL-4- YL)-2(3H)-FURANONES
Author
Asif Husain*, Aftab Ahmad, Shah Alam Khan
Email
drasifhusain@yahoo.com
keyword
Furnaone, Pheretima posthuma, Perionyx excavatus, Anthelmintic.
Abstract
We report herein the anthelmintic activity of 3-arylidene-5-(biphenyl-4-yl)-2(3H)- furanones against two species of earthworms i.e. Pheretima posthuma and Perionyx excavatus. The mean paralyzing and death times of the worms due to compounds at concentration 2mg/mL were recorded for the evaluation of anthelmintic activity. Synthesized furanone derivatives exhibited moderate to good anthelmintic activity but among all tested compounds 1d and 1e were found to be promising against Perionyx excavatus and Pheretima posthuma, respectively. They showed significant anthelmintic activities against both types of worms and the results were comparable to positive control albendazole.
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