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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
PACLITAXEL INDUCED PARALYTIC ILEUS AND REVIEW OF THE LITERATURE
Author
Ali Alkan*, Ebru Karcı, Arzu Yaşar, Elif Berna Köksoy, Muslih Ürün, Güngör Utkan
Email
alkanali@yahoo.com
keyword
Paralytic ileus, Lung cancer, paclitaxel.
Abstract
Paclitaxel, a member of taxanes, is a microtubule stabilizating agent. In oncology practice, besides its activity in lung, ovarian and breast cancer, it’s widely used in other malignancies with different chemotherapy regimens. Nausea, vomiting, cytopenia and hypersensitivity reactions are mostly encountered side effects of the drug. Mild and moderate neuropathy, which is a well known class effect of taxanes, is experienced in 60% of cases. Severe neurological side effects like seizures, syncope and ataxia are noted in 3% of the cases. Autonomic neuropathy related consequences have also been reported in the literature. Here we present a paralytic ileus experience during paclitaxel therapy with the informed consent of the patient.
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