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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
MYELOID METAPLASIA IN PAEDIATRIC AXILLARY LYMPH NODES: A RARE PRESENTATION OF INFANTILE OSTEOPETROSIS
Author
Gaurav Jain, Ila Tyagi*, Anu Maheshwari, Ritu Arora, Namrata Nargotra
Email
drilatyagi@yahoo.co.in
keyword
Osteopetrosis, Myeloid metaplasia, Axillary lymphadenopathy.
Abstract
Osteopetrosis is a rare congenital, heterogeneous group of genetic disorders characterized by increased bone density due to impaired bone resorption by osteoclasts. Abnormal osteoclast activity paired with normal bone formation by osteoblasts leads to the development of densely sclerotic fragile bones. A seven month old male child presented with bilateral axillary lymphadenopathy of two months duration. On examination small palpable 0.5 cms lymph nodes were found bilaterally. On FNAC these lymph nodes showed features of myeloid metaplasia (extra medullary haematopoiesis). Peripheral smear of the patient showed anemia, thrombocytopenia with features of leukoerythroblastosis. Ultrasound showed hepatosplenomegaly. On X ray patient showed generalised thickening of bones. Bone marrow aspiration attempted was unsuccessful. Final diagnosis of Osteopetrosis with extra-medullary haematopoiesis was established. Myeloid metaplasia in lymph node aspirates of a patient presenting with lymphadenopathy and hepatosplenomegaly should raise strong suspicion of Osteopetrosis, which needs to be confirmed on radiology.
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