European journal of molecular biology and biochemistry

SERUM LIPID PROFILE AND ELECTROLYTES IN ESSENTIAL HYPERTENSION

O. Sanahanbi Devi, Davina Hijam, Chubalemla Longkumer, Laljem Haokip, Rupak Das, Abhishek Dubey, Chanchal L Chanu*, Th. Premchand, Th. Ibetombi Devi

davina_hijam@yahoo.co.in

Essential Hypertension, Total cholesterol, LDL-Cholesterol, Triglycerides.

To compare the levels of lipid profile parameters and serum electrolytes (Na+ and K+) in normotensive individuals and in patients with essential hypertension with or without complications. And also to evaluate any association between these parameters and blood pressure. A Case control study carried out in the Department of Biochemistry in collaboration with the Department of Medicine, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, during the period August 2011 to July 2013. Altogether 120 individuals were taken for the study (i.e. 40 normal healthy individuals as control, 40 hypertensives without complication and 40 hypertensives with complication). A study on the lipid profile shows that serum triglyceride (TG), total Cholesterol, low density lipoprotein(LDL), and very low density lipoprotein (VLDL) were founf to be raised above the respective reference ranges and serum high density lipoprotein (HDL) was found to be below the reference range in the hypertensive cases. There was a positive correlation between TC and blood pressure and also between LDL and blood pressure but a negative correlation was found between HDL and blood pressure. The levels of serum sodium ( Na+) and potassium ( K+) conc among the hypertensive group was found to be within the reference range . however a positive association was found between serum (Na+) and blood pressure, but a negative and weak association was observed between serum K+ and blood pressure. Elevated LDL may be responsible for progression of essential hypertension as well as etiogenesis of atherosclerosis and its subsequent complications. The negative correlation of HDL with increased blood pressure suggest a protective role in atherogenesis and also Na+ plays an important role in the etiogenesis of essential hypertension but it cannot be used as a biomarker of hypertension , for few days own homeostatic mechanism tries to maintain serum Na+ level within a narrow range.