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European journal of molecular biology and biochemistry

Volume 11, Issue 1, 2024
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Purchase
Abstract
Title
SERUM LIPID PROFILE AND ELECTROLYTES IN ESSENTIAL HYPERTENSION
Author
O. Sanahanbi Devi, Davina Hijam, Chubalemla Longkumer, Laljem Haokip, Rupak Das, Abhishek Dubey, Chanchal L Chanu*, Th. Premchand, Th. Ibetombi Devi
Email
davina_hijam@yahoo.co.in
keyword
Essential Hypertension, Total cholesterol, LDL-Cholesterol, Triglycerides.
Abstract
To compare the levels of lipid profile parameters and serum electrolytes (Na+ and K+) in normotensive individuals and in patients with essential hypertension with or without complications. And also to evaluate any association between these parameters and blood pressure. A Case control study carried out in the Department of Biochemistry in collaboration with the Department of Medicine, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, during the period August 2011 to July 2013. Altogether 120 individuals were taken for the study (i.e. 40 normal healthy individuals as control, 40 hypertensives without complication and 40 hypertensives with complication). A study on the lipid profile shows that serum triglyceride (TG), total Cholesterol, low density lipoprotein(LDL), and very low density lipoprotein (VLDL) were founf to be raised above the respective reference ranges and serum high density lipoprotein (HDL) was found to be below the reference range in the hypertensive cases. There was a positive correlation between TC and blood pressure and also between LDL and blood pressure but a negative correlation was found between HDL and blood pressure. The levels of serum sodium ( Na+) and potassium ( K+) conc among the hypertensive group was found to be within the reference range . however a positive association was found between serum (Na+) and blood pressure, but a negative and weak association was observed between serum K+ and blood pressure. Elevated LDL may be responsible for progression of essential hypertension as well as etiogenesis of atherosclerosis and its subsequent complications. The negative correlation of HDL with increased blood pressure suggest a protective role in atherogenesis and also Na+ plays an important role in the etiogenesis of essential hypertension but it cannot be used as a biomarker of hypertension , for few days own homeostatic mechanism tries to maintain serum Na+ level within a narrow range.
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