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European Journal of Environmental Ecology

Volume 10, Issue 1, 2023
Mcmed International
European Journal of Environmental Ecology
Issn
XXX-XXXX (Print), 2393 - 9672 (Online)
Frequency
bi-annual
Email
editorejee@mcmed.us
Journal Home page
http://mcmed.us/about/ejee
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Abstract
Title
SUB-CHRONIC TOXICITY STUDIES OF QUIZALOFOP-P-ETHYL IN FEMALE WISTAR ALBINO RATS
Author
US Deshmukh* and SP Dhabe
Email
ujjwaladeshmukh@rediffmail.com
keyword
Quizalofop-p-ethyl, Haematological, Biochemical analysis.
Abstract
Quizalofop-p-ethyl marketed as Targa Super is widely used effective herbicide. An attempt has been made to assess the toxic effect of Quizalofop-p-ethyl, rats were given oral doses of 1/25 of LD50 of the Quizalofop-p-ethyl (59.2 mg/kg of body weight) dissolved in water for 120 days. Haematological analysis shows significant increase in TLC, particularly neutrophil (51.67**± 11.25), lymphocyte (44.17**± 11.58) and eosinophil (2.5**± 1.2247), whereas no any observable changes were found in Hb % and RBC. Where, the biochemical analysis shows significant increase in protein (9. 3**± 0.68), a slight increase in the alkaline phosphatase, cholesterol and potassium, while no variations in the glucose and electrolytes were recorded. A significant increase in the relative weight of lung (1.229**± 0.057609) with a slight increase in weight of the liver and significant decrease in weight of the ovary (0.0515**± 0.0014) was observed. It has been also observed that Qzalofop-p-ethyl induced swelling on intestine and liver. Symptomatic behavioral changes were also observed. Comparing the toxicity of Quizalofop-p-ethyl widespread use of this herbicide in public places is to be prohibited or restricted
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