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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
INCLUSION OF AMPICILLIN TRIHYDRATE IN HIGHLY ORDERED MESOPOROUS SILICA NANOPARTICLES
Author
Suman Jangraa, Vijay K. Tomer, Ashok K. Sharma, Vinod Chhokar, Rahul, Surender Duhan*
Email
surender6561@gmail.com
keyword
Ampicillin, UV-visible spectroscopy, antimicrobial agent
Abstract
Ampicillin was included in the mesoporous silica nanoparticle SBA-15 with pore diameter (8.8 nm) and high surface area (590 m2/g) by the post impregnation method. These inorganic-organic composite were fully characterized by: UV-visible spectroscopy, thermo gravimetric analysis (TGA), X-ray Powder Diffraction (XRPD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Nanocomposite shows decrease surface area from 737 to 114 m2/g and pore diameter 8.8 to 6 nm, which showed that ampicillin had been successfully included in host SBA-15 pore channels with drug entrapment efficiency 72.6 % and drug loading efficiency 53%. Ampicillin loaded SBA-15 presents high loading and hence causes reduction in the toxicity and side effects of the drug which can also be an excellent and long term antimicrobial agent against various pathogenic bacteria’s.
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