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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
EXPRESSION AND LIBERATION OF CHEMOATTRACTANT MOLECULES IN HUVECS INDUCED BY rSSP4 DERIVED FROM T. CRUZI AMASTIGOTES
Author
López-Monteon A*, Morán-Utrera Y, Rosales-Encina JL and Ramos-Ligonio A.
Email
aralopez@uv.mx
keyword
T. cruzi, rSSP4, MMPs and CAMs.
Abstract
During the acute phase of infection, Trypanosoma cruzi replicates extensively and releases immunomodulatory molecules that delay parasite-specific responses mediated by effector T cells. This mechanism of evasion allows the parasite to spread in the host. Parasite molecules that regulate the host immune response during Chagas’ disease have not been fully identified, particularly proteins of the amastigote stage. In this work we evaluated the role of the GPI anchored SSP4 protein of T. cruzi as an immunomodulatory molecule in human umbilical cord (HUVEC). rSSP4 protein was able to induced the expression of genes and production of molecules involved in the inflammatory process, such as, cytokines, chemokines, metalloproteinases (MMPs) and adhesion molecules (CAMs) determined by RT-PCR and ELISA. These results suggest that the amastigote SSP4 molecule could play a key role in the immunoregulatory process observed in the acute phase of infection with T. cruzi.
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